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Idalopirdine Hydrochloride

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Purity:99.97%

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COA HNMR HPLC

Idalopirdine Hydrochloride

Catalog No. T22936Cas No. 467458-02-2

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).

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Pack Size	Price	Availability
1 mg	$97	In Stock
2 mg	$135	In Stock
5 mg	$197	In Stock
10 mg	$283	In Stock
25 mg	$512	In Stock
50 mg	$743	In Stock
100 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$212	In Stock

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Product Introduction

Bioactivity

Description	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is an in-vivo binding affinity and effect, in-vitro selectivity and potency of 5-HT(6)R antagonist (Ki: 0.83 nM).
In vitro	In the 5-HT(6) GTP gamma S efficacy assay, Lu AE58054 showed potent inhibition of 5-HT-mediated activation. Apart from medium affinity to adrenergic alpha (1B)- and alpha(1A)-adrenoreceptors, Lu AE58054 shows >50-fold selectivity compared with more than 70 targets examined[1].
In vivo	In the rats model, Orally administered Lu AE58054 inhibited binding of the 5-HT6 antagonist Lu AE60157 (ED50: 2.7 mg/kg). Administration of Lu AE58054 in a dose range (5–20 mg/kg) leading to above 65% 5-HT6R binding, which reversed cognitive impairment in rats treatment with phencyclidine. These results indicate that Lu AE58054 is a potent antagonist of 5-HT6Rs with good oral bioavailability in the rat model of cognitive impairment in schizophrenia[1].
Alias	Lu AE58054 Hydrochloride, Idalopirdine HCl

Chemical Properties

Molecular Weight	434.83
Formula	C20H20ClF5N2O
Cas No.	467458-02-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 50 mg/mL(114.99 mM)

DMSO: 20 mg/mL(45.99 mM)

H2O: 3 mg/mL(6.90 mM, with ultrasonic and warming)

Solution Preparation Table

Ethanol/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2997 mL	11.4987 mL	22.9975 mL	114.9875 mL
5 mM	0.4599 mL	2.2997 mL	4.5995 mL	22.9975 mL

Ethanol

	1mg	5mg	10mg	50mg
10 mM	0.2300 mL	1.1499 mL	2.2997 mL	11.4987 mL
20 mM	0.1150 mL	0.5749 mL	1.1499 mL	5.7494 mL
50 mM	0.0460 mL	0.2300 mL	0.4599 mL	2.2997 mL
100 mM	0.0230 mL	0.1150 mL	0.2300 mL	1.1499 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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